Use it overnight for an instant appearance of freshness and plumpness to the skin in the morning. Try it for 14 days and see the dramatic anti ageing effects proven in ingredient clinical trials. The Antarctic ingredients also protect the skin from the extreme cold so use this serum in the winter months to defend the skin against the weather. This serum can be mixed into your moisturizer or used by itself on clean dry skin. You can also blend it together with another S5 serum for even quicker results. For example try blending it with the S5 Resilience Serum for a rich nourishing night treatment. KEY INGREDIENTS RAINFOREST BIDENS PILOSA improves skin radiance and texture. Its unique retinoid-like cellular renewal properties increase Collagen I by 24% and functional elastin by 42% in vitro, helping to reduce the appearance of wrinkles by up to 36% and supporting skin density. It boosts the gene expression of Sirtuin-6, involved in cellular longevity, by 2.4x in vitro. It has also been proven to reduce inflammatory markers and free radical activity in vitro. It lightens the appearance of the skin, reducing UV spots by 36%, by reducing melanin synthesis (tested in vitro). ANTARCTIC GLYCOPROTEINS come from a tiny microorganism only found in the extreme cold of Antarctica. It produces proteins to strengthen its cellular walls and defend itself against the extreme cold. On the skin, the proteins dramatically strengthens the cellular matrix and reduce the appearance of wrinkle depth by an average of 44% in 30 days and increase collagen production by up to 128% in 14 days (tested in vitro). They also defend the skin against cold weather, reducing environmental skin stress. LOW MOLECULAR WEIGHT NATURAL HYALURONIC ACID locks moisture into the skin, reduces skin hyper reactivity and stimulates epidermal regeneration.